Mechanisms of ethanol liver damage in rats with different emotionality

Alcoholic liver disease is associated with injury ranging from steatosis to steatohepatitis, fibrosis and cirrhosis. One of the mechanisms organs damage cytokines influences. The intensity depends on individual reactivety.The aim study was evaluate changes in blood interleukins heart high- low-emotional (HE, LE) male rats ethanol hepatosis, hepatitis, cirrhosis determine degree damage.Material methods investigation. experiments were performed 72 HE LE outbred aged 4 months ((control 1, glucose 7 days, acute hepatitis – EH) 120 autbred 5.5-6.5 (control 2, 67 hepatosis EHs, EF, EC). emotionality determined by "open field" method.Determined serum Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β), (IL-4), 10 (IL-10), alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (AP). All animals underwent histological examination heart, right left ventricles (RV, LV), ventricular septum (VS) square.Results. In EH increase IL-1β, IL-10 decrease TNF-α rats. EF EC IL-4 TNF-α, ALT (more LE), AST HE) AP. decreased ALT, increased AST. AP EHs; EC. EC; EHs. both groups at a remodeling observed. earlier bigger observed rats.Conclusion. severity simulated pathology, which more pronounced highly emotional organism different take plase changes. low emotions firosis high